The burning pain in the vagina on the twelfth day of IVF transplantation may be due to the pain induced by the process of fertilized egg implantation, or there may be vaginitis, which needs to be targeted for the cause. 1. The pain induced by the process of fertilized egg implantation: when the test tube is placed, it will pass through the vagina, and the fertilized egg in the process of growing up, the woman will experience some discomfort, such as lower abdominal swelling, increased secretion, and the body’s estrogen increase, as long as there is no obvious bleeding, generally do not carry out special treatment. 2. Vaginitis: If a woman suffers from vaginal inflammation, such as bacterial vaginosis, vulvovaginal pseudomycosis, etc., after IVF transplantation, or due to not paying attention to personal hygiene, she may experience burning pain, or accompanied by abnormal vaginal discharge, vaginal odor and other symptoms. It can be treated with medication under doctor’s guidance, such as local use of mycotoxin tablets, nifurtimox suppositories and other medications. After IVF transplantation, you should pay attention to personal hygiene, keep the vulva clean, and consult a doctor in time if you have vulvovaginal itching or abnormal secretions.