High platelets with early myelofibrosis may be characterized by anemia, splenomegaly, and hypermetabolic state. 1. Primary thrombocythemia is caused by abnormal proliferation of megakaryocytes, manifested by elevated platelets, which belongs to chronic myeloproliferative neoplasms, and myelofibrosis of different degrees can occur. Bone marrow fibrosis is caused by the proliferation of collagen in bone marrow hematopoietic tissue, which can affect the hematopoietic function. 2. The condition of primary thrombocythemia develops slowly, if not treated effectively, part of it can be transformed into myelofibrosis, which can be manifested in the early stage as anemia symptoms such as pale mucous membranes, fatigue, different degrees of splenomegaly, symptoms of high metabolism state such as low fever, night sweating (abnormal sweating after going to sleep, and sweating stops after waking up), weight loss, and so on. When primary thrombocythemia occurs, it should be standardized under the guidance of a doctor to avoid delays.