Dryness of the whole palm may be related to physiological factors such as climate and detergents, or pathological factors such as keratosis pilaris, keratotic eczema, palmoplantar keratosis, and so on. 1. Physiological factors: daily life if the environmental climate is dry, or often use irritating detergents, may lead to the emergence of the whole palm of the dry situation. 2. Pathologic factors: (1) Keratosis pilaris: caused by fungal infection of the skin, often showing rough skin, deepening of skin lines, cracking, itching, etc., which may lead to the appearance of the whole palm of the hand dry. (2) Keratosis pilaris: mainly due to early acute eczema, subacute eczema improper treatment or untimely, resulting in recurrent episodes caused by, often showing skin dryness, flaking, and in severe cases, cracking may occur, which may lead to the emergence of the whole palm of the hand dry conditions. (3) Palmoplantar keratosis: mainly due to genetic factors, external environmental stimuli, vitamin deficiency, etc., often showing roughness of the palmoplantar skin, thickened plaques, pimples, cracks, etc., which may lead to the emergence of the whole palm of the hand dry conditions. Therefore, it is recommended that if the above symptoms occur, if necessary, choose to seek medical treatment to identify the causes and early treatment.