Diabetic polyneurological damage is diffuse throughout the body, mainly demyelination, axonal degeneration and peripheral neuritis, and the main symptoms are systemic abnormalities and local abnormalities. Systemic abnormalities are mainly manifested by pain, abnormal skin sensation, and even itching of the skin. Local abnormalities are mainly manifested in a certain part of the body, such as abnormal sensation in the lower extremities, such as pain and numbness in the toes, loss of sensation, and a feeling of stepping on cotton when walking. In the heart area, tachycardia at rest or hypotension after changing from lying to standing position may occur, and the symptoms may include dizziness, weakness, darkness or fainting when getting up or standing, and in severe cases, painless myocardial infarction or even sudden death. When it affects the gastrointestinal tract, it can manifest as delayed gastric emptying, which is called gastroparesis. The main symptoms include epigastric fullness, belching and even nausea and vomiting, abdominal pain, etc. There can also be diarrhea and constipation alternately. When affecting the gonads, it can lead to sexual dysfunction, such as loss of libido, impotence, premature ejaculation, etc. When it affects the urinary tract, there is mainly relaxation of the bladder sphincter, which is called diabetic neurogenic bladder, and the main symptoms include dysfunction of urination, and women are prone to urinary tract infections. In summary, diabetic neuropathy is a systemic damage, so the performance can be in the whole body, can be localized, or may be both, regardless of which performance should be detected as early as possible for early treatment.