High lipoprotein a considers the presence of atherosclerosis, acute myocardial infarction, familial hypercholesterolemia, congenital hyperlipoproteinemia, diabetes mellitus, aortic aneurysm and some cancers in the body, and is an independent risk factor for many cardiovascular diseases. 1. Atherosclerosis: Atherosclerosis is caused by a variety of factors, and its pathogenesis is complex and has not yet been fully elucidated. The main risk factors include hypertension, hyperlipidemia and smoking, as well as diabetes, obesity and genetic factors. 2. Acute myocardial infarction: most patients occur on the basis of atherosclerotic stenosis of coronary arteries. Due to certain triggers, coronary atherosclerotic plaque rupture, blood platelets in the blood accumulate on the surface of the ruptured plaque to form a blood clot, suddenly blocking the coronary artery lumen, resulting in myocardial ischemia and necrosis. 3. Familial hypercholesterolemia: Familial hypercholesterolemia is a rare autosomal dominant disease with family characteristics. Patients have abnormally high low-density lipoprotein (LDL) cholesterol values. High LDL-A is also seen in congenital hyperlipoproteinemia, diabetes mellitus, aortic aneurysm and some cancers, etc. It is recommended to go to the hospital for a clear diagnosis and active treatment.