Painless gastroscopy is usually not life-threatening. Painless gastroscopy refers to the injection of short-acting anesthetics on top of ordinary gastroscopy, so that the patient belongs to a sedated and anesthetized state, relieving the pain and discomfort caused by ordinary gastroscopy, and then waking up after the gastroscopy. Anesthesia has certain risks, before the examination the doctor will give the patient anesthesia assessment, liver and kidney function tests, blood routine, cardiovascular and cerebrovascular examination, etc. The patient should truthfully inform the past history and allergy history. If the patient suffers from cardiac insufficiency, arrhythmia, or respiratory disease it is not recommended to do painless gastroscopy, otherwise it will aggravate the patient’s condition. Patients should also comply with the medical advice, fasting and water before anesthesia, pay attention to the diet after the examination, mainly fluid and soft food, and do not engage in fine and dangerous work.