In March of this year, Helen followed my advice to have an abortion and an embryonic chromosome test, the result of which was: 45XY, -C. It was a chromosome fragment deletion and early termination of pregnancy prevented further suffering and the possibility of a child with congenital defects being born. Helen had received free preconception care at my preconception clinic, but her menstrual cycle was postponed before the full report of the test was available, and a urine test showed that she was indeed pregnant. Helen was almost two months pregnant when she returned to the clinic. She had a small amount of vaginal bleeding two weeks ago and had been prescribed some birth control medication at another hospital. I reviewed her preconception health file and all preconception test data were normal, but the environmental exposure history stated, “Newly married and newly decorated with new furniture, furniture material is veneered laminate, pungent odor after moving in.” The guidance column then reads, “It is recommended to hold off on conception and consider again after being tested by a professional testing company to confirm that no harmful substances have been exceeded.” A small amount of vaginal bleeding during early pregnancy is called pre-eclampsia, and according to reports, this phenomenon occurs in nearly 30-40% of pregnant women, most of which is caused by the luteinizing hormone and placental hormone bruising. But it’s hard to say whether a history of adverse environmental exposure will have an effect. Let’s have an ultrasound! The ultrasound shows “a gestational sac is seen in the uterus, but no germ is visible”. Normally, on day 52, the ultrasound can detect a germ that is about 15mm in length and the primordial fetal heartbeat can be seen. At the time of Helen’s follow-up, she was 56 days from her last menstrual period and had not yet seen a germ, which, in light of her medical history, was not good. Thus the situation described in the beginning of the film emerged. The dangers in life are not always easy to detect Helen’s case is of a more definite nature, but in practice, we are often unable to find a definite cause. Often patients who have had spontaneous abortions or even born with congenital defects ask for a thorough examination before they get pregnant again to avoid a similar situation again. As a physician, I would first consider the infection, immune and endocrine aspects, do some relevant tests and check the karyotype of both parties if necessary, but most of the results are normal, while the issue of environmental factors is the most difficult to consider and forensic. More than 80% of my preconception clients answered no when I asked if they had any exposure to risky environmental factors, and when I gave a random example, he or she started laughing and scratching their heads. In my preconception health education, I grouped harmful environmental factors into three major categories: i. Physical: various types of radiation from computers, cell phones, microwaves, high temperatures, electromagnetic fields, long-term noise stimulation, etc.; ii. Chemical: tobacco, alcohol, drugs, paints, lacquers, hair dyes, cosmetics, problem foods from the agricultural economy, etc.; iii. Biological: bacteria, viruses, other microorganisms such as toxoplasma carried by pets. Subtracting for risk factors However, the focus of my missionary work is not to tell you which factors are influential, because everyone’s working and living environment is different, I can’t cover everything, and I’m not an authority in this area, I can’t know all kinds of factors very well, the so-called missionary guidance is just to provide you with a thought and method to analyze the problem. The idea is to follow the three lines I cited to analyze. The first method is to carry out self-criticism, the focus is to be careful, from near to far carefully recall what they have done in the past 4-6 months and the environment they have been exposed to, followed by seeking criticism everywhere, mobilizing couples to find “problems” with each other, mobilizing colleagues, relatives, friends around to find The second thing is to seek criticism from all over the world, to find “problems” among couples, and to mobilize colleagues, relatives and friends around you to find “problems”, to summarize and organize your problems, and to remind yourself of them during the process of pregnancy preparation. If you have questions about the problems summarized or when you have to be exposed to certain environments for certain occupations, then your health care practitioner can come in handy to address your questions and learn about relevant protection so that you can get targeted solutions. I was very impressed by a very interesting young man in the preconception health clinic. When I asked him, who was a heavy smoker, to start quitting, he asked me if he could smoke less, or only the good brand and expensive ones. I didn’t give him a positive answer, but also asked him two questions: Are all children born to smokers stupid? Are all children born to people who drink alcohol missing their arms and legs? The answer is not necessarily, just a higher probability. Then I ask, if I smoke today, and drink, recently got sick, and took medicine? Then of course the probability is higher! In fact, these questions are just to tell you that the problems we find are not the decisive factors that cause birth defects, but rather are influencing factors, and when multiple influencing factors are superimposed on each other, the risk of causing spontaneous abortion or birth defects increases. In fact, we now live in an environment where there are too many influencing factors, and can not be prevented: drink a glass of milk, melamine; eat a piece of chicken, estrogen is elevated ……, may be what is exposed to the media tomorrow. So, before pregnancy we do more preparation is not possible to do zero risk, but as long as we pay attention and efforts, we can minimize the probability of our risk. Is it enough for me to stop smoking and drinking for a month before my wife gets pregnant? How far in advance do I have to start preparing before I get pregnant? The correct answer is 4 to 6 months in advance. Because the growth cycle required for human male sperm to develop from a primitive spermatogenic cell to a mature sperm is 74 days, and similarly for women, although they menstruate once a month and ovulate one egg, this egg starts to grow before 85 days. In contrast, tobacco, alcohol, drugs and other influencing substances after entering the body, through absorption, metabolism, and then excretion, there is a half-life gradual reduction process. Therefore it is easy to understand that a preparation period of 4 to 6 months is needed. In addition, if a couple is sick during the preparation period, the majority of them will be infectious or contagious diseases such as colds and diarrhea, and a common feature of these diseases is that they all have an incubation period, which varies from one pathogen to another, for example, the incubation period of influenza virus is about one week, that of hepatitis B virus can be three months, and that of HIV can be as long as six months. long ……. Therefore, if you think your preconception preparations are not safe enough, implement your birth control measures. Staying away from harmful work environments and creating a healthy living environment is the first requirement to ensure a healthy baby. For the sake of your baby, please stay away from harmful environments and join the ranks of low-carbon environmental protection for the sake of your baby’s baby.