Tubular toxicity lesions are caused by immunosuppressive drugs and anticancer drugs toxic nephropathy, which refers to the lesions of glomeruli, tubules and interstitium as well as bladder damage due to the application of immunosuppressive drugs and anticancer drugs. Kidney is the main organ of metabolism and excretion of drugs and poisons in the body, and in the process of its metabolism and excretion, it can produce toxic effects on the kidney in a variety of ways, resulting in renal damage and the occurrence of toxic nephropathy. According to the history of exposure to nephrotoxic substances, patients with suspected nephropathy should have blood routine, urine routine, bilateral renal ultrasound, pyelogram, renal scan, renal biopsy (electron microscopy report), urine examination, renal function tests, etc. Kidney is the main organ for the metabolism and excretion of drugs and poisons in the body, and in the process of its metabolism and excretion, it can produce toxic effects on the kidney in many ways, causing kidney damage and toxic nephropathy. In recent years, due to the clinical application or abuse of a wide range of drugs, the incidence of drug-induced acute and chronic renal failure is increasing, especially in the elderly and patients with pre-existing renal disease is particularly prominent. Normal human kidney blood flow accounts for 25% of the whole body, and the weight of the kidney is only 0.4% to 0.5% of the body weight, so the kidney is the body’s blood flow of the most abundant organs, a large number of drugs and their metabolites with the blood flow to the kidney, easy to the kidney to produce direct toxic effects.