High rheumatoid factor and pain all over the body need to be combined with the rheumatoid factor, X-ray, ultrasound, etc. to determine the cause of the disease, such as the presence of rheumatoid arthritis or other diseases, and for the cause of the symptomatic treatment. 1. Whether there is rheumatoid arthritis: in patients with rheumatoid arthritis, 70% to 80% of the population may have a significantly elevated rheumatoid factor, so it should be the first need to exclude the presence of rheumatoid arthritis. Combined with the patient’s symptoms of small joint swelling, joint X-ray performance, ultrasound examination of whether there is synovitis and other means to diagnosis. 2. If the diagnosis of rheumatoid arthritis can be confirmed: it is necessary to use anti-inflammatory and pain-relieving drugs under the guidance of the doctor, and to start anti-rheumatic drugs such as prednisone and methotrexate as early as possible for the treatment of rheumatoid arthritis, pay attention to warmth, and check C-reactive protein, blood sedimentation rate, rheumatoid factor and other indexes regularly. 3. Rule out other diseases: infectious diseases such as tuberculosis infection, malignant tumors can also cause elevated rheumatoid factor and generalized pain, which need to be treated according to the cause. If you have high rheumatoid factor, body pain, or other symptoms, you should go to the hospital in time, and give targeted treatment after clarifying the cause.