The treatment of chronic moderate gastritis with severe intestinalization mainly includes dietary adjustment and other general treatment, eradication of Helicobacter pylori, protection of gastric mucosa, improvement of gastrointestinal dynamics and other drug therapy and surgical treatment, as follows. 1. General treatment: patients with chronic moderate gastritis with severe intestinal diet should be light, easy to digest, abstain from smoking and alcohol, avoid spicy stimulation, heavy salt and pickled barbecue food, maintain a good state of mind and sleep. 2. Drug therapy: For H. pylori-related chronic moderate inflammation with severe intestinalization should be given to the combined program for the eradication of H. pylori treatment. Acid-suppressing agents, gastric mucosal protective agents can be used to relieve abdominal pain and acid reflux symptoms, and gastrointestinal dynamics drugs can be used to relieve abdominal distension and other symptomatic treatments. 3. Surgery: Chronic gastritis with severe intestinalization and cancerous tendency can be treated with submucosal dissection under gastroscope, and regular follow-up is required. Chronic moderate gastritis with severe intestinalization is recommended to consult the doctor as soon as possible for standardized treatment to avoid delaying the condition.