Appendiceal cancer is a common anorectal disease, and there are many causes of appendiceal cancer, so do you know what causes appendiceal cancer? If you don’t know much about this disease, please take a look. Common causes of appendiceal cancer Genetic factors: Family members with family history of appendiceal cancer have 2-6 times higher risk of appendiceal cancer than the general population. Several genes as well as genetic diseases cause great danger to appendix cancer: familial polyposis, Turcot syndrome, Gardner syndrome, juvenile polyposis, Cowden’s disease, neurofibromatosis. Parasitic diseases: Our data show that some advanced schistosomiasis is also complicated by cecum cancer. It is generally believed that the long-term deposition of schistosome eggs on the colonic mucosa can cause repeated ulceration, repair and chronic inflammation of the mucosa, resulting in adenomatous hyperplasia, on the basis of which carcinoma can occur. History of colon diseases: Certain colon diseases such as Crohn’s disease or ulcerative colitis may increase the chance of colorectal cancer. Their risk of colon cancer is 30 times higher than that of the general population. Polyps: Most colorectal cancers develop from small precancerous lesions, which are called polyps. Among them, villous adenoma-like polyps are more likely to develop into cancer, with a chance of malignancy of about 25%; tubular adenoma-like polyps have a malignancy rate of 1-5%. What are the early symptoms of cecum cancer? Changes in bowel habits and stool characteristics are often the earliest symptoms. Abdominal pain is also one of the early symptoms, which is often a persistent hidden pain with inaccurate localization, or only a feeling of abdominal discomfort or bloating, but it may be aggravated by intestinal obstruction or paroxysmal colic. Most of the abdominal masses are the tumor itself, and sometimes they may be the accumulation of feces in the intestinal lumen proximal to the obstruction. Most of the masses are hard and nodular in shape. In the case of transverse colon and sigmoid colon cancer, there may be some degree of activity. If the cancer penetrates and is complicated by infection, the mass is fixed and there is obvious pressure pain. The symptoms of intestinal obstruction are generally the late symptoms of colon cancer, mostly manifested as chronic low-level incomplete intestinal obstruction, mainly manifested as abdominal distension and constipation. The abdomen is distended and painful or paroxysmal colic. When complete obstruction occurs, the symptoms are aggravated. Left-sided colorectal cancer can sometimes have acute complete colon obstruction as the first symptom. Systemic symptoms may include anemia, emaciation, weakness and low fever due to chronic blood loss, cancer ulceration, infection, toxin absorption, etc. In advanced stage of disease, hepatomegaly, xanthogranuloma, swelling, ascites, anterior rectal mass, supraclavicular lymph node enlargement and cachexia may appear. Due to the different pathological types and locations of cancer, the clinical manifestations are also different. Generally, right-sided colon cancer is mainly manifested by systemic symptoms, anemia and abdominal mass, while left-sided colon cancer is significantly manifested by symptoms such as intestinal obstruction, constipation, diarrhea and blood in stool.