Trigeminal neuralgia is characterized by electric shock-like, cut-like, tear-like pain in the distribution area of the trigeminal nerve, which is sudden and stops abruptly and lasts for a few seconds to tens of seconds each time, with completely normal intervals. Differential diagnostic methods include physical examination, neurological examination, and clinical manifestations. 1. Trigeminal neuralgia needs to be differentiated from dental pain, but the physical examination of dental pain has the manifestations of swollen and painful gums and limited mouth opening. 2. Trigeminal neuritis also has persistent facial pain, but neurological examination reveals hypesthesia in the area of trigeminal nerve distribution. 3. Hypoglossal neuralgia and trigeminal neuralgia have the same nature of pain, but hypoglossal neuralgia is usually located in the tonsillar fossa and the root of the tongue. 4. Pterygopalatine neuralgia should also be differentiated from trigeminal neuralgia, but pterygopalatine neuralgia is burning, persistent, and irregular. Patients with the above symptoms are advised to consult a doctor in time for early diagnosis and timely treatment to avoid delay.