Normal men also produce small amounts of estrogen. In clinical practice estrogen can also be used as an adjunctive treatment for male diseases, such as prostate tumors and prostate hyperplasia. Short-term use of estrogen has a small effect, but long-term use of estrogen in 60-year-old men may lead to low function of the reproductive system, feminized manifestations and so on. Long-term use of estrogen will lead to endocrine system disorders, excessive estrogen in the body, affecting the male reproductive system, such as atrophy of testicular tissue, affecting semen and sexual function; affecting the level of androgens, leading to thinning of the voice, pitch, breast development and other feminized manifestations; long-term use of hormones may also lead to obesity, depression and so on. Estrogen should be taken under the guidance of a doctor, do not take on your own.