Types of non-insulin hypoglycemic agents 1.sulfonylurea agonists; 2.biguanides; 3.alpha-glucosidase inhibitors; 4.thiazolidinediones (insulin sensitizers); 5.glargonides (non-sulfonylurea agonists); 6.dipeptidyl peptidase-4 (DPP-4) inhibitors; 7.glp-1 analogues; 8.sglt-2 inhibition. Indications for non-insulin hypoglycemic agents For the treatment of type 2 diabetes mellitus whose blood glucose control does not reach the standard even after dietary control and exercise therapy. Action sites of various non-insulin hypoglycemic agents Principles and precautions for the selection of non-insulin hypoglycemic agents 1. safe and effective; 2. avoid severe hypoglycemia and control weight gain; 3. for those whose blood glucose control still does not reach the standard by monotherapy, the combination of drugs should be used (early combination, strong combination, complementary mechanism, reduce side effects and slow down the speed of failure); 4. take the drugs on time and have good compliance.