Children who have had HFMD may or may not get it again. HFMD is a disease caused by intestinal viral infections. Common viruses that can cause HFMD include Coxsackie virus group A types 2, 6, and 16. Generally speaking, antibodies to the corresponding viruses are produced after HFMD. Due to the presence of antibodies, the same type of enterovirus will not cause recurrent infections in children, but there is no cross-immunity between different types of enterovirus, and infections with other types of viruses can still cause the disease in children again. Therefore, it is important to pay attention to hygiene in order to prevent children from being infected with other types of enteroviruses, and if abnormal symptoms occur, they should go to the hospital as soon as possible for review and receive standardized diagnosis and treatment in a timely manner.