Children’s lead poisoning can involve many systems, such as the nervous system, hematopoietic system, digestive system and endocrine system, etc. The clinical manifestations are very complicated and lack of specificity, so it is necessary to consult the doctor in time for a clear diagnosis. 1. Nervous system: the most vulnerable to lead damage, which can cause sensory or motor nerve disorders, and in severe cases, develop into toxic encephalopathy and even lead to coma and other serious disorders of consciousness. 2. Hematopoietic system: lead can inhibit the synthesis of hemoglobin and affect the absorption of iron, thus causing iron deficiency anemia. 3. Digestive system: Characteristic manifestations are metallic taste in the mouth and persistent abdominal cramps, in addition to nausea, vomiting, diarrhea and other symptoms. 4. Endocrine system: lead can inhibit the secretion of vitamin D activating enzyme as well as growth hormone, causing growth and developmental disorders in children. Children’s lead poisoning must be taken seriously, through the test blood lead and urine lead content can be diagnosed, once diagnosed need to immediately consult a doctor, follow the doctor’s instructions to take appropriate treatment measures, so as not to miss the opportunity for treatment.