Toxic shock syndrome this disease is very uncommon in our lives, but this disease is real around us, we do not want ourselves to be plagued by this disease, so what are the diagnostic criteria for toxic shock syndrome? All of us should want to know the answer to this question, the following we will give you a detailed introduction to it. Toxic shock syndrome is a syndrome characterized by fever, rash, syncope, hypotension or shock and multi-system lesions, mostly caused by one or more toxins produced by Staphylococcus aureus. 1. Sudden onset of high fever. 2. The rash is often a diffuse red maculopapular rash. 3. Skin flaking occurs 1 to 2 weeks after onset. 4. hypotension or upright syncope. 5. damage to at least 3 or more organs throughout the body. 6. Negative or positive bacterial cultures of blood, pharyngeal swabs, and cerebrospinal fluid. The diagnosis can be confirmed if all of the above points are met, or the absence of any one of the above points is considered a suspicious case. To differentiate from adult Kawasaki disease and staphylococcal scarlet fever, blood, vaginal and nasal secretions and urine cultures should be done to observe the presence of Staphylococcus aureus and to exclude the possibility of other pathogenic bacterial infections. Pathogen culture and serologic tests are the key to the diagnosis of this disease. Leukocytosis, left shifted nuclear phase, thrombocytopenia in some patients, prolonged prothrombin time, liver function or renal function abnormalities, blood, nasal, pharyngeal and vaginal secretion culture can isolate coagulase-negative Staphylococcus aureus (phage group I). There are no characteristic histologic manifestations; the dermis may have perivascular single nucleated cell infiltration and papillary layer edema, and in cases with blister formation, fissuring occurs in the subepidermis. What is the diagnostic criteria for toxic shock syndrome this problem we know a lot, only we ourselves have an understanding of the disease we can live a healthy life, in our lives we will encounter a lot of diseases, as long as we seriously face the disease we can better protect ourselves, I hope that we can all live a healthy life.