Types of poison: 1, common pesticides: including organophosphorus pesticides, ethyllicin, various herbicides such as chrysanthemum cyanoacetic esters, dimethoate, etc., and insecticides, including imidacloprid chlorpyrifos, manfrotto, muriatic acid, and so on. All kinds of drugs are also an important cause of poisoning. 2, common drugs: including psychotropic drugs such as clomipramine, clozapine, apremilun, fenestrazine, haloperidol, pentafluridol and so on. Antidiarrheal drugs such as prescription diphenoxylate; antihypertensive drugs such as Topril, compound tetrazine Lipitor, nimodipine, compound antihypertensive tablets. Even anti-rheumatic drugs such as Pau tazone, anti-tuberculosis drugs rifampicin; hypoglycemic drugs: glibenclamide. In addition, there are also ziprasidone, nitrite, potassium permanganate, furadan, vinblastine, digoxin, ketamine and other drugs and so on. There are also rodenticides, alcohol, cyanide, strong acids and alkalis, including kerosene, concentrated sulfuric acid and so on. Poisoning mode: 1, with “dichlorvos water” hair washing caused by dichlorvos severe poisoning, the rest are accidental poisoning. 2, alcohol poisoning. Clinical manifestations: 1, neurological abnormalities accounted for 69.3%, mostly poor mental health, lethargy, irritability, coma, convulsions, of which 2/3 of the patients appeared in the electroencephalogram in the severe abnormalities 2, digestive abnormalities accounted for 31.6%, mostly vomiting, stress ulcers, gastrointestinal hemorrhage, accompanied by oral mucous membrane burns in 5 cases. 3.Respiratory abnormalities accounted for 22.7%, mainly manifesting changes in respiratory rhythm and shallow breathing. 4, liver function abnormalities accounted for 56%, acute renal failure, more than half of the patients with low-moderate fever, individual patients with localized skin burns. Treatment: organophosphorus pesticides and rodenticides, psychotropic drugs poisoning, more than one conscious disorder, drowsiness, irritability, coma, convulsions, and even fever, and a considerable number of parents do not know the child accidentally take drugs or pesticides, so it is very easy to misdiagnose as viral encephalitis. Here we need to pay special attention to, once diagnosed as acute poisoning, immediately give the removal of toxic substances treatment: 1, on the accidental administration of drugs, poisons: within 12h are given to emetic, gastric lavage, diarrhea; rehydration to maintain the electrolyte balance, dehydration, diuresis, to promote the excretion of poisons; protection of the gastrointestinal mucosa, to protect the heart, liver, kidneys and other important organs, such as the function of the comprehensive symptomatic treatment. 2, to the skin absorption of poisoning: with a lot of water to wash hands, head, eyes, ears, skin, etc.. 3, the immediate application of special antidotes: according to the different types of poisoning, give the appropriate antidote, such as organophosphorus poisoning early with isopentyl quinhydrin hydrochloride or atropine, antiphosphidine, etc.. 4, serious patients with central respiratory depression and respiratory failure, immediately give oxygen therapy, mechanical ventilation and other respiratory support; circulatory failure to give appropriate fluid resuscitation and vasoactive drug applications, while early blood perfusion, blood filtration to remove the poison, in the above treatment on the basis of intravenous nutritional support. Pediatric acute poisoning focus on prevention, the focus of prevention in rural areas. Firstly, the management of pesticides should be strengthened, and the commonly used insecticides, herbicides and rodenticides should be properly stored and put in a place where children can’t get in touch with them. Secondly, to strengthen the management of medicines, parents should be fed to children according to medical advice, in the child’s illness should try to pediatricians and pharmacists under the guidance of medication, medication should be carefully examined before the drug and its expiration date, do not arbitrarily increase the amount of or abuse of adult medicines, to be indiscriminate, wrong or increase the dose of medicines to take the hazards of a sobering understanding. Medicines at home should be properly placed and not allowed to be casually accessed by children, especially sweetened medicines (with sugar coating) and antipsychotic drugs. Parents should educate children not to pick up food, not to play with utensils with toxic substances, such as empty bottles or plastic bags filled with pesticides, not to take things in their mouths at random, and cultivate good hygiene habits and living habits in children to reduce the occurrence of acute poisoning in children. At the same time, it is also important for medical institutions to publicize anti-poisoning knowledge and appropriate treatment methods to all sectors of the community to prevent poisoning.