The combination of rifampicin and isoniazid may cause acne on the face, which may be induced by allergic inflammation caused by the side effects of the drug. Most of the anti-tuberculosis drugs have certain adverse reactions, such as liver and kidney function damage, gastrointestinal reactions and allergic reactions, etc.; isoniazid’s more common adverse reactions are mainly gastrointestinal reactions and peripheral neuritis; rifampicin’s common adverse reactions are hepatotoxicity, gastrointestinal reactions and allergic inflammation. Therefore, the occurrence of allergic reactions during the administration of these two drugs is generally considered to be caused by rifampicin, and it is recommended that the dosage of the drug should be adjusted by a specialist or the drug should be replaced if necessary. Rifampicin is contraindicated for those who are allergic to rifamycin antibacterial drugs and those with severe hepatic insufficiency; isoniazid is contraindicated for patients with abnormal hepatic function, psychosis and epilepsy. In addition, the application of the above drugs have certain risks, patients need to get the guidance of a specialist.