Most patients with advanced stages of HIV cryptococcal encephalitis can be cured if treated promptly. Cryptococcal meningitis is an infectious disease of the central nervous system caused by a novel cryptococcal infection. If standardized antifungal therapy and systemic supportive therapy are given in time, it can usually be cured with a good prognosis. If treatment is not given in time, the disease will progressively worsen, with a poor prognosis or even life-threatening. Cryptococcal meningitis is a deep-seated fungal disease in which, after a few weeks or months, intracranial pressure may rise and cerebral nerves may be involved, usually with changes in fundus exudates and retinal exudates. Psychiatric symptoms such as depression, apathy, and irritability may sometimes be present, and later hemiparesis, ataxia, convulsions, and coma may occur. It is recommended that patients with cryptococcal meningitis should seek timely medical treatment, and be given antifungal therapy, intravenous or oral fluconazole, itraconazole, flucytosine and other drugs, and pay attention to dehydration to reduce intracranial pressure, and be given 20% mannitol intravenous drip as prescribed by the doctor, to prevent cerebral hernia formation. If the patient is complicated with hydrocephalus, shunt surgery can be given.