Lateral knee pain, generally common causes are lateral meniscus injury, lateral collateral ligament injury, patellofemoral osteoarthritis, etc., can be treated with medication through oral medication and topical medication, etc., to relieve the symptoms. 1. Lateral meniscus injury: it is common in traumatic injury caused by sudden twisting action when bending the knee and degenerative injury caused by long-term friction of meniscus. Non-steroidal anti-inflammatory drugs such as ibuprofen and celecoxib can be taken orally to reduce inflammation and pain. Oral medications to protect the cartilage, such as glucosamine sulfate, can also be taken to prevent additional damage to the cartilage brought about by the meniscus injury. 2. Lateral collateral ligament injury: Lateral collateral ligament injury is commonly caused by knee inversion due to direct violence on the outside of the knee joint. Non-steroidal anti-inflammatory drugs such as ibuprofen and celecoxib can be taken orally, and topical medications such as sodium rosoprofen gel cream can be taken to the affected area, which is beneficial to eliminating the inflammation and reducing the pain. 3. Patellofemoral osteoarthritis: Patellofemoral osteoarthritis is a chronic joint disease due to degenerative changes in the cartilage of the articular surfaces and osteomalacia, which may cause symptoms of lateral knee pain. Oral non-steroidal anti-inflammatory drugs such as diclofenac sodium and celecoxib may be taken. Oral medications that slow down cartilage degeneration, such as chondroitin sulfate, can also be effective in slowing down cartilage degeneration. There may be other reasons for lateral knee pain, so it is recommended to go to the hospital in time, complete the examination to clarify the cause of the disease, and then give targeted treatment or therapy. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse effects.