Eyelid swelling in renal failure may be caused by diseases leading to sodium retention, hypoproteinemia and other reasons. Patients with renal failure have impaired excretion of metabolic wastes and water, resulting in sodium retention and fluid accumulation, which may lead to the phenomenon of eyelid swelling; or various renal diseases resulting in renal failure, due to the excretion of a large amount of proteinuria, resulting in hypoproteinemia, plasma colloid osmolality decreases, and water leakage from the intravascular to the extravascular, which may be manifested as eyelid swelling in the clinical situation. If patients with renal failure have swollen eyelids, they need to limit fluid intake, apply diuretics such as furosemide, torasemide and other treatments; at the same time, for the primary disease, it is feasible to use hormones such as prednisone acetate, immunosuppressants such as cyclophosphamide, cyclosporine and other treatments, and dialysis treatment if necessary. Patients with swollen eyelids in renal failure may also have other reasons, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.