The gastroesophageal valve is one of the barrier structures at the gastroesophageal junction. Gastroesophageal valve grading is an endoscopic method of evaluating the status of GERD, which is generally categorized into Grade I, Grade II, Grade III and Grade IV depending on the condition. Grade II is generally not serious, and specific cases require comprehensive consideration and diagnosis by a medical professional. Grade I patients have a pronounced ridge of tissue at the gastroesophageal junction that tightly wraps around the endoscope; Grade II patients show occasional relaxation based on Grade I following respiratory movements; Grade III patients have a ridge of tissue that does not tightly wrap around the endoscope; and Grade IV patients have a complete opening of the gastroesophageal region. In general, both grades I and II are normal and not serious enough to require special intervention. If a patient with grade II GERD has a relatively long course of disease and has Barrett’s esophagus, there is a risk that this pathology may develop into precancerous or cancerous lesions, which is a relatively serious condition that should be treated as soon as possible. Therefore, when abnormalities occur, patients should consult a doctor in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of a professional physician, so as to avoid delaying the condition and leading to adverse consequences.