Acne can be caused by abnormal hormone levels, clogged pores or exuberant sebaceous gland secretion, etc. Depending on the situation, you can use the right medication to help remove it. 1. Abnormal hormone levels: If you are in puberty, the androgen activity in your body increases, and the hormone levels in your body are out of balance, which can lead to acne on both sides of your cheeks. You can use topical fusidic acid cream, mupirocin ointment, etc. These antibiotic creams have the effect of inhibiting and killing Propionibacterium acnes, which can alleviate the symptoms of acne on both sides of the cheeks caused by abnormal hormone levels. 2. Pore blockage: when the keratinization of the sebaceous gland ducts of the cheek follicles is abnormal, the follicle opening will become smaller and cause blockage, and the sebum can’t be discharged normally and accumulates in the follicle opening, thus causing the phenomenon of cheek acne. Daily should do a good job of face cleaning, you can use anti-keratinizing drugs for treatment, such as retinoic acid ointment, salicylic acid ointment and so on. 3. Sebaceous gland secretion: such as often stay up late, like spicy greasy stimulation will make the sebaceous gland secretion increase, should pay attention to adjust the lifestyle, light diet. All of the above medications should be used in accordance with medical advice. If you have acne on both sides of your cheeks, you need to maintain a light diet, get enough sleep, clean your skin well, and go to the hospital as soon as possible for regular treatment.