Thick yellow nasal discharge from the nose is most commonly seen in rhinitis and sinusitis caused by bacterial infections and often requires antibiotic medications and mucus promoters. Nose with snot may be caused by inflammation of the nasal cavity or sinuses, usually when there is a bacterial infection, it will lead to a yellow discharge, can be treated with oral antibiotic drugs, such as roxithromycin, azithromycin, amoxicillin, etc., which can play the role of anti-inflammatory and bactericidal, and help to improve the inflammation. In order to promote the outflow of nasal discharge, it can also be combined with mucus pro-drainage, and the commonly used medication is eucalyptus-pinocampus. Commonly used glucocorticoid drugs to reduce inflammation and swelling, such as budesonide nasal spray, mometasone furoate nasal spray and so on. With physiological seawater nasal spray to clean the nasal cavity can promote the recovery of nasal mucosal cilia function, and promote the drainage of pus. Nose with thick yellow snot should be timely to the hospital, systematic examination, clear cause, follow the doctor’s instructions to standardize the use of medication and treatment, avoid self diagnosis and treatment and medication, to reduce the occurrence of adverse reactions and drug side effects.