Herpes zoster is caused by varicella-zoster virus infection and is not associated with HIV, therefore the onset of herpes zoster does not affect HIV testing. Herpes zoster is an infectious disease that involves the nerves and skin and can be cured with prompt treatment. HIV, on the other hand, is an acquired immunodeficiency syndrome that cannot be completely cured. Therefore, the onset of herpes zoster does not affect HIV testing. False positives may occur when the test reagents are out of date or when the patient has other autoimmune diseases. False positives can also be caused by medical staff errors and the use of certain medications. When the HIV test is positive, it is important to consult a doctor, complete the examination to make a clear diagnosis, and follow the doctor’s instructions to carry out targeted treatment.