The pain in the middle of the spine should be alert to autoimmune diseases such as ankylosing spondylitis, supraspinous ligament or interspinous ligament injuries, lumbar disc herniation, spinal tumors and infectious lesions and compression fractures of the spine and other lesions. 1. Autoimmune diseases: such as ankylosing spondylitis, usually occurring in young adults, accompanied by morning stiffness and other discomforts, pain is usually more pronounced at night, and most of the patients have positive hematological examination of HLAB27. 2. Supraspinous ligament or interspinous ligament injury: usually with a history of spinal strain or trauma, the pain will be triggered or aggravated when the spine bends. 3. Lumbar intervertebral disc herniation: usually accompanied by pain and discomfort or numbness in the lower limbs, which can be clearly diagnosed by CT or MRI. 4. Neoplastic and infectious lesions of the spine: such as nerve sheath tumor and spinal tuberculosis, etc., which need to be combined with physical examination and MRI to make a clear diagnosis. 5. Compression fracture of the spine: mostly occurring in the elderly or menopausal women or patients with trauma to the spine. Spinal pain in the middle of the spine to be alert to the disease is more, if the rest does not relieve or recurring need to go to the hospital in time, a clear diagnosis.