Chickenpox and herpes zoster belong to the same pathogen, mainly caused by varicella zoster virus infection, but there will still be some difference, mainly in the incidence of population, clinical manifestations and infectious differences. 1. The onset of the population: chickenpox is common in children and adolescents, usually occurring after the initial infection with the virus, while herpes zoster is due to varicella zoster virus infection latent in the nerve roots, in the human body when the immune system is low, so herpes zoster disease age is older. 2. Clinical manifestations: chickenpox is mainly distributed throughout the body, trunk, limbs, scalp, face can appear scattered erythema, blisters, may have mild itching symptoms, or asymptomatic. Herpes zoster is generally unilateral or single site attacks along the nerve root, manifested as a band-like distribution of clustered erythema, blisters, and accompanied by obvious and even severe pain. 3. Contagiousness is different: generally speaking, chickenpox is more contagious in the population, while herpes zoster is relatively less contagious to healthy adults. Patients should pay close attention to chickenpox and shingles, and should follow the doctor’s instructions to give the corresponding treatment and therapy after diagnosis.