Simvastatin can stabilize plaque. Simvastatin is a lipid-lowering drug that can be used to treat hyperlipidemia, hypercholesterolemia, or mixed hyperlipidemia. However, the use of simvastatin should also be combined with dietary control to provide the best plaque stabilization and lipid control. The diet is recommended to take into account the proportions and composition of the Mediterranean diet with a total calorie count. It is also important to take active physical exercise to control the causes of atherosclerosis, such as high blood pressure, high blood cholesterol, high blood sugar, obesity and smoking, in order to maintain maximum lipid stability and stabilize the plaque so that it does not easily rupture and thrombosis occurs.