Mother was 64 years old. Preoperative diagnosis of left main, three branch angiopathy, unstable angina and type 2 diabetes mellitus. On July 4, 2014, a non-stop coronary artery bypass graft was performed under general anesthesia with postoperative low cardiac output IABP assist, and the patient was discharged 7 days after surgery. At six months follow-up, there were no angina attacks and other cardiovascular events, and the quality of life was significantly improved. Son, 41 years old, was admitted in early July 2014 with sudden onset of chest tightness and pain in the precordial region. 3 coronary stents were implanted in an external hospital 6 years ago due to acute coronary syndrome. The coronary angiography suggested that all the vessels far from the left main stem were occluded, all the stents were occluded, the anterior descending branch was reversibly visualized by the right coronary, the right coronary stenosis was 90%, the mitral valve had a lot of regurgitation, and the left ventricular ejection fraction was 39%, which could be described as a life-threatening situation. After preoperative medical treatment, when myocardial markers were basically normal, ultrasound suggested moderate mitral valve closure insufficiency, non-stop coronary artery bypass grafting was performed on July 24, 2014 with the assistance of extracorporeal circulation under general anesthesia, with three bypasses and satisfactory bridge flow. Postoperative shutdown was difficult and was treated with the assistance of extracorporeal membrane pulmonary ECMO + IABP (intra-aortic balloon counterboost), and was discharged 18 days after surgery. Song Shiqiu, Cardiac Surgery Center, Beijing Anzhen Hospital Coronary heart disease has a genetic tendency. In recent years, the author has treated many cases of close relatives such as father, son, brother, sister, mother, son, etc. Often, the former generation has not been operated for a long time, and the latter generation is hospitalized for treatment, indicating that coronary heart disease has a trend of gradual rejuvenation in recent years, which should be paid great attention. Usually pay attention to quit smoking and alcohol, reduce weight, and actively treat hypertension, diabetes and hyperlipidemia. Unsatisfactory medical treatment, left main trunk lesions, three branch vascular lesions, proximal anterior descending branch lesions, combined valve disease, left ventricular ventricular wall tumor, left ventricular thrombus and its atrial fibrillation, post-stent angina, etc. should be actively treated surgically. Currently, the author’s surgical group has a success rate of over 99% for coronary artery bypass graft patients.