Urine protein (++++) suggests that there is a large amount of proteinuria in the urine, which is often caused by renal disease and is not life-threatening and is certainly salvageable. First of all, you need to go to the nephrology department of the hospital to check the 24h urine protein quantification, to assess the leakage of protein in the urine, and at the same time further examination of renal puncture to clarify the specific type of pathology. The more common causes of urinary protein (++++) are nephrotic syndrome, lupus nephritis, diabetic nephropathy, IgA nephropathy and so on, which need to be selected according to the different causes of targeted treatment programs. Nephrotic syndrome requires hormone or immunosuppressant treatment, while diabetic nephropathy is mainly treated with ACEI or ARB drugs and symptomatic treatment such as controlling blood sugar. The presence of a large amount of proteinuria will have a certain degree of damage to the kidneys, but also cause hypoproteinemia, edema and other complications, pay attention to infections, as well as thrombosis, pre-renal renal insufficiency and other complications.