Right upper abdomen pain is not necessarily a precursor of liver cancer, but may also be caused by cholecystitis, pancreatitis and other diseases. Hepatocellular carcinoma starts insidiously and often has no obvious clinical symptoms in the early stage, and the appearance of obvious symptoms mostly indicates that the disease has entered the middle or late stage. Clinical manifestations of liver cancer in middle and late stages include persistent distending pain or dull pain in the right upper abdomen, liver size, yellow staining of skin and sclera, ascites, emaciation, loss of appetite, malnutrition, etc. There are many reasons for liver cancer pain in the right upper abdomen. The causes of right upper abdominal pain are many, including not only liver cancer, but also hepatitis, cholecystitis, gallbladder stones, pancreatitis, etc. Further examination, such as abdominal ultrasound, abdominal CT, etc., should be carried out in time to further clarify the causes of right upper abdominal pain. Therefore, patients with right upper abdominal pain should go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease and then give targeted treatment in a timely manner.