Thrombo-occlusive vasculitis is caused by the occlusion of small and medium-sized arteries in the extremities due to inflammation of the entire blood vessel wall, resulting in severe ischemia of the extremities, mostly in the lower extremities, clinically manifesting as intermittent claudication in the early stage and severe resting pain, ulceration and blackening necrosis of the extremities in the late stage, eventually requiring high amputation. The cause of this disease has not been completely clear, mostly seen in the cold areas of the north, most often in young and strong males, mostly with a long-term history of heavy smoking. The disease cannot be completely cured because it mainly causes occlusion of small and medium-sized arteries in the extremities. Traditional vasodilatation, blood-vitalizing drug therapy and various surgical therapies are not effective. In recent years, the author applied interventional treatment of thrombo-occlusive vasculitis, has achieved significant results, interventional treatment, namely balloon dilation, stent implantation, by opening the maximum extent of the occluded segment from the vascular cavity, can improve the blood supply of the affected limb to the maximum extent, save the limb, especially for patients with large and medium artery occlusion, the effect is significant, immediate results, and interventional treatment is minimally invasive treatment, less invasive, fast recovery, is interventional treatment is minimally invasive, less invasive and faster recovery, and is the treatment of choice at present. The patient was a 52-year-old female with a 15-year history of thrombo-occlusive vasculitis who had undergone artificial vessel bypass of the left femoral N artery 15 years ago. Intraoperative angiography revealed complete occlusion of the left external iliac artery, superficial femoral artery and main artery below the knee, and the artificial vessel was occluded. After interventional treatment (balloon dilation and stenting), the left external iliac artery and superficial femoral artery were completely opened.