HPV52 positive persistent infection for 8 years, it is recommended to go to the hospital, because it is HPV52 is a relatively high-risk HPV virus subtype, if it has been persistently infected for 8 years, it is possible that cervical lesions may have existed, and it is necessary to carry out a cervical exfoliative cytology or take biopsy to do a pathology examination to clarify. If high-risk HPV52 is positive combined with a positive TCT test, further colposcopy and biopsy are needed to decide what to do next based on the colposcopy. If there is no cervical lesion, regular TCT and HPV tests are needed to reduce the risk of cervical cancer. Meanwhile, HPV infection should be actively treated. Common treatments include physical therapy such as laser, medication such as interferon and traditional Chinese medicine. In life, we should pay attention to avoid unclean sex, especially multiple sexual partners, so as not to cause inflammation and increase the risk of lesions, and appropriate exercise to improve the body’s immunity. If diagnosed with cervical cancer, patients should choose appropriate treatment plan according to their age and reproductive needs, and common treatment methods include surgery, radiation therapy, chemotherapy, targeted therapy, etc. In addition, patients should keep a good mood, avoid bad life habits, exercise properly and pay attention to personal hygiene.