HPV53 positive belongs to high-risk HPV infection, which is related to sexual life, but it is not contagious through sexual contact, which means that unmarried women with no history of sexual life will not have high-risk HPV infection, and only women who are married or have a history of sexual life will have the possibility of high-risk HPV infection. High-risk HPV infection may lead to pre-cancerous lesions on the cervical epithelium, which may even develop into cervical cancer, so when HPV53 infection is detected what should be done is a colposcopy to find out if there are lesions on the cervical epithelium. If there is no lesion, review regularly, and if there is a lesion, deal with it promptly.