Atypical squamous cell HPV positivity should mean that atypical squamous column cells are visible on cervical TCT cytology and HPV positivity suggests that the epithelium of the uterine cervix may be diseased and further examination is required. 1. Atypical squamous cells: can be detected by genital tract exfoliative cytology i.e. cervical TCT screening. It includes atypical squamous cells without clear diagnostic significance and atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesions. 2. HPV positive: HPV is categorized into high-risk and low-risk types. High-risk types such as HPV16, 18, 31, etc. can easily lead to cancer and precancerous lesions; low-risk types such as HPV6, 11, 42, etc. are mainly prone to cause low-grade squamous intraepithelial lesions and genitourinary warts. When cervical cancer screening results return TCT can see atypical squamous cells without clear diagnostic significance or cannot exclude high-grade squamous intraepithelial lesions with atypical squamous cells, and at the same time combined with HPV positivity, it is necessary to go to the hospital to do further examination, such as colposcopic biopsy, and according to the results of the decision on the next step in the treatment program, to avoid blindly using medication on their own, which will result in the progression of the disease, malignant changes and other consequences.