Generally speaking, the failure of two IVF transplants may be caused by the problem of the embryo itself, insufficient endometrial tolerance, immune factors, etc. It is recommended to seek medical advice to clarify the cause of the disease and then carry out symptomatic treatment.
1. Problems with the embryo itself: most cases are caused by chromosomal abnormality of the embryo, which looks normal on the surface and divides very fast, but there are internal problems, which affect the growth and development of the embryo, resulting in the death of the embryo and failure to implant.
2. Inadequate endometrial tolerance: endometrial tolerance is a function that allows the embryo to adhere, invade and induce a series of changes in the endometrial mesenchyme, thus leading to embryo implantation. Poor endometrial tolerance is an important factor in embryo transfer failure.
Endometrial morphology, volume, thickness, lesions, hormone levels, etc. will have a certain impact on endometrial tolerance.
3. Immune factors: Embryo implantation is a successful semi-homologous transplantation, which needs to be regulated by the immune system, and the embryo is like a foreign thing in the mother’s body, once a strong immune response occurs, antibodies will be produced, which will lead to the failure of implantation, and you can choose to use glucocorticosteroids, third-party lymphocyte immunotherapy, and so on.
If the two IVF transplants do not implant can go to the relevant hospital for examination, under the guidance of the doctor for treatment, usually also pay attention to diet and work and rest, regulate the body.