High thyroid stimulating hormone may be caused by subacute thyroiditis, primary hypothyroidism and other diseases, whether it can be self-healing needs to be determined according to the situation, if it is a patient with subacute thyroiditis, it can usually be self-healing, and if it is a primary hypothyroidism, it can not be self-healing in general. Thyroid stimulating hormone is secreted by the pituitary gland and plays a key role in the control of the hypothalamic-pituitary-thyroid axis, which promotes the development of thyroid cells, synthesis and secretion of thyroid hormones. Subacute thyroiditis is a self-limiting disease and treatment merely relieves symptoms. Thyroid hormone replacement therapy may be used in symptomatic patients during the hypothyroid period and generally has a better prognosis. Patients with high thyroid stimulating hormone due to primary hypothyroidism usually require lifelong levothyroxine replacement therapy and do not recover spontaneously. The causes of high thyroid stimulating hormone are many and it is recommended to be under the supervision of a medical professional.