If you didn’t get the smallpox vaccine when you were young and grew up, you usually don’t need to make up for it. Smallpox vaccine is a biological agent used to prevent smallpox virus infection. Smallpox virus has caused a large number of deaths in history, but with the advancement of science and technology, there are no smallpox virus infected people in China, and there have not been any smallpox patients for a long time. If you didn’t take smallpox vaccine when you were young and grew up, you usually don’t need to make up for it because in 1980, the World Health Organization has already declared the eradication of smallpox, and you basically can’t run into any smallpox virus carriers in the country, and there is no source of infection, which means that there is no danger of being infected by the smallpox virus, so even if you don’t take the vaccine for smallpox, you will not have any problems.