Taking metformin extended-release tablets for stomach upset can be improved by adjusting the time of taking the medicine, changing to a different dosage form, and adjusting the treatment regimen. 1. Adjusting the time of taking the medicine: Metformin is not affected by the time of taking the medicine, and the time of taking the medicine can be changed to take it after or during meals to minimize the adverse reactions in the gastrointestinal tract. 2. Changing different dosage forms: you can change metformin extended-release tablets to metformin enteric-coated tablets. Enteric-coated tablets are not digested in the stomach, but only digested and absorbed in the intestines to take effect, which can reduce the stimulation of the stomach. 3. Adjust the treatment program: If the symptoms of gastric distress cannot be improved, the treatment program can be adjusted according to the patient’s blood glucose under the guidance of the doctor, and other kinds of hypoglycemic drugs can be chosen for treatment. Drugs need to be used rationally under the guidance of the doctor.