Ankle cartilage wear is mainly seen in young or elderly patients who are overly active. The main manifestation is ankle pain, which is aggravated by walking and can be alleviated at rest. For patients with a history of trauma, this is the early stage of traumatic arthritis. In terms of treatment, we should reduce walking activities, which is the fundamental and prerequisite for treatment, and at the same time, we can take oral glucosamine sulfate to nourish cartilage and promote cartilage self-repair. After early treatment, most people can alleviate or even recover completely, but if further repair is not done, the wear and tear will aggravate, which will lead to articular cartilage exfoliation and cause osteochondritis of the whole ankle joint. At the late stage of arthritis, there is not much effect through oral medication or conservative treatment, and the function of the ankle joint needs to be sacrificed to fuse the joint and relieve the pain symptoms.