The fPSA/tPSA ratio is normal should be >0.25, if fPSA/tPSA <0.15 suggests the presence of prostate cancer risk.
Prostate-specific antigen (PSA) exists specifically in the epithelial cells of the prostate ducts, about 80% of PSA exists in the blood in a composite form, i.e., composite PSA (cPSA), and about 20% exists in a free form, i.e., free PSA (fPSA), and the total PSA is tPSA. fPSA/tPSA should be >0.25 under normal circumstances.
When malignant changes occur in the prostate, or hyperplasia, inflammation, etc., there will be varying degrees of elevated PSA. When prostate cancer exists, there will be elevated fPSA and PSA, while fPSA/tPSA decreases. Generally, tPSA >10ng/ml, and tPSA at 4~10ng/ml while fPSA/tPSA <0.15 suggests that prostate cancer is more likely.
While tPSA in 4~10ng/ml while fPSA/tPSA ≥0.15 suggests that it may be caused by benign prostate disease or operation, such as prostate hyperplasia, prostatitis, prostate massage.
It is recommended that people with abnormal fPSA/tPSA ratio should consult a doctor for further examination and treatment.