Hereditary white spots on the hands are considered to be related to diseases such as anaplastic nevus and vitiligo. It can be treated by topical medication, oral medication and, if necessary, phototherapy and surgery. 1. Aberrant nevus: the cause of aberrant nevus has not been fully clarified, and it is considered to be related to congenital autosomal dominant inheritance. The patient may appear corresponding symptoms at birth or soon after birth. There is no specific drug treatment for nevus pigmentosus. For patients with cosmetic needs, it can be covered by masking cream or autologous epidermal transplantation. 2. Vitiligo: the cause of the disease is not clear, the medical research is believed to be related to mental factors, melanocyte crash, heredity and so on. Mometasone furoate, halometasone and other topical hormone creams can be given to prevent proliferation and restore some of the skin color. It can also be treated by light therapy to restore the color of white spot skin or transplantation surgery to achieve the purpose of pigment recovery. There are more types of white spots, such as lichen planus, simple furfura, idiopathic punctate white spots, hypopigmentation and so on. It is recommended not to use drugs blindly, but to go to the dermatology department of regular hospitals for examination first, combined with the advice of specialists, to choose the appropriate way of treatment.