If the pain in the calf in the middle of the night is unbearable, symptomatic treatment should be carried out according to different reasons. Calf pain in the middle of the night may be due to cold, poor blood circulation caused by neuropathic pain, this situation should be given to the patient for massage, physiotherapy, acupuncture points, and hot compresses and other methods of treatment, can play a very good effect. If the sharp pain in the calf in the middle of the night is due to muscle spasm is usually said to be caused by cramps, the main thing is to lift the spasm, you can move, knead or injections such as valium injection, can play a certain role. If the sharp pain in the calf in the middle of the night is caused by rheumatism or rheumatoid diseases, you can carry out anti-inflammatory treatment and use painkillers, which can play a very good role. If the severe pain in the calf in the middle of the night is due to lumbar disc herniation and other compression of the nerves, the main thing is to relieve the lumbar spine compression of the nerves, you can gently massage the lumbar region, you can also pull the legs, stretching the lumbar region after the compression relief. If the situation of severe pain in the calf in the middle of the night is serious, the self-help approach can not be effective, should go to the hospital in time for examination and treatment.