Hepatitis B virus 1.16E+05 is not very serious. Hepatitis B virus 1.16E+05 is a low level of viral replication and is not particularly serious. Further liver function tests can be performed to see if the liver is damaged. If the liver has been damaged, or there is a family history and other high-risk factors, the patient needs to receive antiviral and anti-hepatic fibrosis treatment, antiviral oral drug activity is strong, can be relatively fast inhibition of viral replication, and has a better efficacy for most patients; at present, the clinically commonly used antiviral oral drugs are entecavir, tibivudine, lamivudine, etc., and for the treatment of anti-hepatic fibrosis drugs, including anluo huaibiao pill, activating blood and removing stasis capsule, and so on. For anti-hepatic fibrosis treatment, the drugs include Anluohua Fibroblast Pill and Activating Blood and Removing Blood Stasis Capsule. Patients should stop drinking alcohol in daily life, have a reasonable diet, and do regular checkups. If the test result of hepatitis B virus is abnormal, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment or therapy with the help of a doctor, rather than blindly using medication on their own.