Patients who stay up all night belong to serious sleep disorders, often associated with changes in physiological factors, psychological factors, environmental factors, or related to neurological, psychiatric and somatic diseases, specifically to consider the following issues: 1. Note that patients may have psychiatric disorders, such as patients with depression, anxiety, somatoform disorders and other problems, can lead to the performance of patients who stay up all night. Especially if the patient suddenly suffers from mental trauma and stimulation, it is easy for the patient to have the problem of sleepless nights. 2. It may be that the patient has restless legs syndrome that leads to sleepless nights, because the patient will have the feeling of extreme discomfort in both lower limbs and the patient wants to urgently walk on the ground to alleviate the symptoms. 3. Organic brain diseases cause, such as autoimmune encephalitis, can cause serious insomnia in patients.