The causes of malaise and headache may include the following: 1. Vascular neurological headache, severe vascular neurological headache may cause persistent or intermittent headache as well as fatigue, nausea, vomiting, etc. 2. Infectious diseases, such as intracranial infection, acute purulent tonsillitis, upper respiratory tract infection, lung infection, urethritis, etc., may cause headache, fever, general malaise, joint pain, poor circulation, etc. 3, 3, insomnia, long-term chronic insomnia patients can also appear weakness, dizziness, headache, mental lethargy and other symptoms. 4, anxiety disorders, long-term stress or negative life events can cause patients in a state of anxiety, anxiety disorders, including weakness, headache, decreased appetite, less talkative and other symptoms.