Pain between the bones all over the body may be caused by the following reasons: 1. It may be caused by rheumatic diseases. For example, rheumatism or rheumatoid arthritis may invade many joints throughout the body and cause pain between the bones. 2. It may be caused by infectious diseases. For example, when there is influenza or reactive arthritis, it may cause pain between the muscles, bones and joints of the whole body due to infection, and then produce the above symptoms. 3. It may be caused by overexertion. For example, if the patient does excessive labor or fitness exercises, it may lead to soreness in multiple joints throughout the body. 4. It may be caused by joint instability. For example, if a patient has an unstable joint due to congenital factors, he or she may feel pain in the joints of the whole body during the activity.