The skull is not only a protective layer for the soft tissues of the brain, but also an important guarantee for the aesthetics of the head. Life is often full of accidents, and perhaps an inadvertent collision can cause a piece of our skull to be lost. If not repaired in time, not only the normal functional environment of the brain is not guaranteed, but also it will cause a great burden to the patient psychologically. So, what are the materials that can be used for skull repair surgery? Materials are the most important for skull repair surgery. A good material can not only improve the success rate of the surgery. And it can reduce the chance of post-operative complications. Thousands of years ago, there were doctors tried to use various materials for skull repair, limited by the backward medical knowledge and technical means at that time, there were no suitable materials for doctors to choose. With the advancement of medicine, more and more cranial repair materials have become available for use. Plexiglass, light apatite and calcium phosphate bone cement materials, which were once used in clinical practice, were gradually withdrawn from the medical arena due to their poor clinical results. The commonly used material for cranial repair today is titanium mesh, which is also a quality material with long-lasting application and good results. However, the metallic properties of titanium mesh often have consequences for patients such as sensitivity to cold and heat reactions and CT image errors. Thanks to the efforts of medical researchers, a new type of cranial repair material has been applied above the clinical level, and that is the PEEK material used by the Civil Aviation General Hospital. The material is known as polyether ether ketone, a polymer biomaterial that is extremely close to human cranial bone in terms of elasticity, heat transfer, hardness, and stability, etc. The use of three-dimensional shaping of the PEEK bone plate can be completely compatible with the cranial structure, without worrying about precision and aesthetics. Numerous clinical cases have shown that there are no discomfort or complications associated with PEEK cranial bone repair materials, so PEEK is undoubtedly the best choice for cranial bone repair today.