Chronic appendicitis in women is most often characterized by right lower abdominal pain, but needs to be differentiated from chronic pelvic inflammatory disease, adnexitis, and irritable bowel syndrome. Most patients with chronic appendicitis have a clear history of acute appendicitis that has not been treated surgically. The main manifestation is limited pressure pain in the appendix, i.e., in the right lower abdomen, which is fixed in position, and may be associated with gastrointestinal symptoms such as nausea and vomiting. Clinically, it is often necessary to distinguish it from other diseases with similar symptoms: 1. Chronic Pelvic Inflammatory Disease (CPD): It is characterized by pain in the lower abdomen, a feeling of falling and soreness in the lumbosacral region, and in some cases, fever and vaginal bleeding. It is usually caused by reproductive tract infection, and can be diagnosed by gynecological examination, laboratory examination and imaging examination. 2. Adnexitis: manifested by lower abdominal pain, increased vaginal discharge. It is caused by infection of fallopian tube and ovary. The diagnosis can be made by asking the patient’s medical history, gynecological examination, and laboratory tests. 3. Irritable Bowel Syndrome (IBS): long-term recurrent abdominal pain and abnormal defecation are the main clinical manifestations. It may be accompanied by upper gastrointestinal symptoms such as acidity and heartburn. It can be comprehensively judged by colonoscopy, abdominal CT and ultrasound. Lower right abdominal pain in women may also be caused by other diseases, so they should go to the hospital in time for laboratory tests, physical examination, abdominal imaging (such as ultrasound, CT, etc.), in order to make a clear diagnosis and then be treated accordingly.